Difference between revisions of "Kutaj as h3r inverse-agonist"

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(Created page with "Kutaj is an Auyrvedic medicine, containing about 0.5% - 1% conessine. <br> In India, it is given for infants, as part of an general-infant formula, and by itself to fight acut...")
 
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Conessine agonized the α2c adrenergic receptor <br>
 
Conessine agonized the α2c adrenergic receptor <br>
 
(note Guanfacine is α2b α2c agonist, as beneficial to PWS https://www.liebertpub.com/doi/pdf/10.1089/cap.2018.0102) : <br>
 
(note Guanfacine is α2b α2c agonist, as beneficial to PWS https://www.liebertpub.com/doi/pdf/10.1089/cap.2018.0102) : <br>
https://pubs.acs.org/doi/pdf/10.1021/jm8003625
+
https://pubs.acs.org/doi/pdf/10.1021/jm8003625 <br>
 
http://hightowerpharmacology.blogspot.com/2012/12/future-pharmacy-ii.html <br>
 
http://hightowerpharmacology.blogspot.com/2012/12/future-pharmacy-ii.html <br>
  
 
Conessine bioavailability : https://journals.sagepub.com/doi/abs/10.1177/1469066718756226
 
Conessine bioavailability : https://journals.sagepub.com/doi/abs/10.1177/1469066718756226

Revision as of 05:17, 10 April 2020

Kutaj is an Auyrvedic medicine, containing about 0.5% - 1% conessine.
In India, it is given for infants, as part of an general-infant formula, and by itself to fight acute diarrhea:
Kutaj in infants : https://www.ayurtimes.com/holarrhena-antidysenterica-pubescens-kurchi-kutaj/
http://www.thepharmajournal.com/archives/2014/vol2issue11/PartA/5.1.pdf
Kutaj in infants, as a cure for diarrhea : https://www.ejmanager.com/mnstemps/82/82-1501302642.pdf?t=1544944078
Kutaj contains 0.5%-0.9% of conessine : http://shodhganga.inflibnet.ac.in/bitstream/10603/7229/17/17_chapter%209.pdf

Conessine is very selective to the H3R : https://pubs.acs.org/doi/pdf/10.1021/jm8003625
conessine is also inverse agonist to the H3R : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430196/
“ … In view of the fact that the human histamine H3 receptor is known to be constitutively active [38], evidence for this was sought in terms of demonstrating inverse agonist action of the antagonist ligands. Given the low expression level of this cell line very little constitutive activity would be expected to be seen, and indeed this was the case. Only conessine, thioperamide, ranitidine and cimetidine were found to be inverse agonists in this relatively low expressing cell system. However, this nonetheless confirmed the constitute nature of this receptor. …”
Conessine agonized the α2c adrenergic receptor
(note Guanfacine is α2b α2c agonist, as beneficial to PWS https://www.liebertpub.com/doi/pdf/10.1089/cap.2018.0102) :
https://pubs.acs.org/doi/pdf/10.1021/jm8003625
http://hightowerpharmacology.blogspot.com/2012/12/future-pharmacy-ii.html

Conessine bioavailability : https://journals.sagepub.com/doi/abs/10.1177/1469066718756226