TMG/Methylation

As I understand it, TMG is supposed to promote methylation. Methylation should dial down/turn off genes. This might be a good thing if your child has PWS UPD because your child has received a double dose of mom's genes and a double dose of those genes has been linked to autistic tendencies, so maybe it is good to suppress their expression/dial them down.

UPD

Interesting bit of information relating to Danny’s TMG - I had stopped giving him the TMG and folic acid simply because I ran out and kept forgetting to order it. A couple weeks ago his therapist asked me if anything had changed in Danny’s diet or medication, etc because he was really not acting himself.. He had some weird ‘autistic’ tendencies – going off by himself, not listening to the teachers, very obstinate and not wanting to do what he was told.. Slightly disruptive. I told her that he hadn’t been getting those supplements but I was going to refill and get him back on it.. well, he’s back on it and believe it or not, completely back to normal. Totally focused again and doing what is asked of him, etc etc.. so.. you may be right about the TMG and kids with UPD.

Deletion

In contrast to UPD, kids with PWS deletion do not have any extra genetic material. Instead, they are just missing Dad's contribution. In the best possible world, you would like to dial up expression of mom's turned off (methylated) genes. Therefore logic (if it applies!) would suggest that TMG is not a good idea for kids with PWS deletion.

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